We finally sold our DPMS LR-308. Thank God because that thing was seriously calling to me and I want to stick to the small caliber rifles at this time.
I think your suppressed FN .45 will make an ideal home defense package. No need for hearing protection and no worries about hearing loss. I'd CCW a suppressed pistol if it were feasible. Too damned long though.
Well, you've already mentioned the S&W M&P15-22 and there's the Chiappa dedicated AR-15-22. I've never seen the Chiappa so can't comment on it's quality but can say I've owned two Chiappas, one was a 1911-22, one of the worst pistols I've ever had the displeasure to own. Sold it. The other is a 2" Rhino which I find very well made and carry it frequently. So in my experience with Chiappa is hit and miss.